Single Best Answer (SBA) · Cirrhosis and Chronic Liver Disease
A patient presents with a large-volume upper GI bleed. Which of the following is a recognised cause of upper GI bleeding to consider alongside oesophageal varices?

Show answer and explanation
Answer: D. A Mallory-Weiss tear at the cardia after violent vomiting
Causes of upper GI bleeding
Upper GI bleeding arises proximal to the duodenojejunal flexure. Recognising the range of causes guides endoscopic assessment.
Common causes
| Site | Causes |
|---|---|
| Oesophageal | Varices (portal hypertension), Mallory-Weiss tear (tear at the cardia after violent vomiting), reflux oesophagitis, oesophageal cancer |
| Gastric | Gastric ulcer, gastric cancer, acute gastritis |
| Duodenal | Duodenal ulcer |
| Other | Dengue fever, angiodysplasia, coagulopathy (including liver disease) |
Why the distinction matters
- In a cirrhotic, varices are the priority, but other causes (e.g. peptic ulcer) are common and endoscopy distinguishes them.
- The Mallory-Weiss tear classically follows a bout of violent vomiting/retching.
Lower GI causes (for contrast)
Diverticulosis, haemorrhoids, angiodysplasia of the colon and anal fissures cause lower GI bleeding, not upper.
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