True/False MCQ · Breast Imaging and Biopsy
Regarding age-related benign breast disease, which of the following are TRUE?
- AFibroadenoma is a premalignant lesion
- BJuvenile hypertrophy is a disease of the involution phase
- CFibroadenoma is typical of the early reproductive age group (15-25 years)
- DCyclical mastalgia with nodularity is typical of the mature reproductive group (25-40 years)
- EDuct ectasia and periductal mastitis are features of the involution phase (40-55 years)
Show answers and explanation
- A. False: Fibroadenoma is benign and not premalignant.
- B. False: Juvenile hypertrophy belongs to the early reproductive phase, not the involution phase.
- C. True
- D. True
- E. True
Age-related benign breast disease (ANDI)
Many benign breast conditions are aberrations of normal development and involution, clustering by age.
| Age group | Phase | Typical conditions |
|---|---|---|
| 15-25 | Early reproductive (lobular development) | Fibroadenoma (giant, multiple), juvenile hypertrophy |
| 25-40 | Mature reproductive (cyclical hormonal) | Cyclical mastalgia with nodularity, fibroadenosis/fibrocystic disease, generalised enlargement |
| 40-55 | Involution | Cysts/cystic disease, sclerosing adenosis (lobular); nipple discharge, periductal mastitis, duct ectasia, non-lactational abscess, mammary duct fistula (ductal) |
Malignant potential
Fibroadenoma is benign and not premalignant; large fibroadenomas do not increase cancer risk.
Why A is false
Fibroadenoma is not premalignant.
Why B is false
Juvenile hypertrophy is an early reproductive, not involution, phase condition.
Why C is true
Fibroadenoma is the classic early reproductive lesion.
Why D is true
Cyclical mastalgia with nodularity is typical of 25-40 years.
Why E is true
Ductal involution disorders occur in the 40-55 involution phase.
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