True/False MCQ · Routine Antenatal Care
Concerning Down syndrome screening in antenatal care, which of the following statements are TRUE?
- AA high-risk screening result confirms the diagnosis without further testing
- BCombined first-trimester screening includes nuchal translucency and serum PAPP-A
- CThe quadruple test is used when nuchal translucency cannot be measured
- DA thicker nuchal translucency increases the estimated risk of Down syndrome
- EScreening for trisomy 21 is recommended for all women as part of routine antenatal care
Show answers and explanation
- A. False: A high-risk screen prompts a diagnostic test (karyotype), it does not confirm the diagnosis.
- B. True
- C. True
- D. True
- E. True
Down syndrome screening
Trisomy 21 screening is offered to all women, with the test chosen by gestation and feasibility of NT measurement.
Tests
- CFTS: NT (11+2 to 14+1 weeks) + hCG and PAPP-A (10+0 to 14+1 weeks).
- Quadruple test: hCG, AFP, unconjugated oestriol, inhibin A (14+2 to 20+0 weeks) when booking late or NT cannot be measured.
Why A is false
A high-risk screen leads to an offer of a diagnostic test; it does not confirm the diagnosis.
Why B is true
CFTS combines NT with serum hCG and PAPP-A.
Why C is true
The quadruple test is used when NT cannot be measured or for late booking.
Why D is true
A thicker NT increases the estimated Down syndrome risk.
Why E is true
Trisomy 21 screening is recommended for all women routinely.
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