Regarding features that favour Crohn's disease over ulcerative colitis, the following are TRUE:

• A. True
• B. False: The rectum is usually spared in Crohn's disease; mainly rectal involvement favours ulcerative colitis.
• C. False: Toxic megacolon is more characteristic of ulcerative colitis, not Crohn's disease.
• D. True
• E. True

Features favouring Crohn's disease

Distinguishing CD from UC is a core clinical distinction.

Crohn's-favouring features

• Cobblestone mucosa.
• Non-caseating granulomas.
• Transmural inflammation (hence strictures, fistulae, perianal disease).
• Skip lesions; terminal ileal involvement; rectal sparing.

UC-favouring features (for contrast)

• Continuous disease from the rectum; superficial (mucosal) inflammation; crypt abscesses; toxic megacolon is the more characteristic complication of UC.

Statement-by-statement verdict

Why A is true

Cobblestoning is characteristic of Crohn's.

Why B is false

The rectum is usually spared in Crohn's; mainly rectal involvement favours UC.

Why C is false

Toxic megacolon is more characteristic of UC, not Crohn's.

Why D is true

Non-caseating granulomas favour Crohn's.

Why E is true

Transmural inflammation is a Crohn's feature.