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Flashcard · Gallstones and Biliary Disease

What are the risk factors for gallstones?

Answer

The classic 'five Fs': fat, female, fertile (multiparous), forty, and fair. Also haemolytic disorders (pigment stones), and causes of biliary stasis - diabetes, pregnancy, oral contraceptives, and prolonged fasting/TPN.

Clinical relevance. The five Fs and stasis/haemolysis risk factors help identify patients prone to gallstones.

More Detail

Risk factors for gallstones

Several factors increase the risk of gallstone formation.

The classic 'five Fs'
  • Fat (obesity).
  • Female.
  • Fertile (multiparous).
  • Forty (middle age and older).
  • Fair.
Other
  • Haemolytic disorders (chronic haemolysis predisposes to pigment stones).
  • Biliary stasis: diabetes, pregnancy, oral contraceptive use, and prolonged fasting on TPN.
  • Family history, high-fat diet.

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